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Methotrexate, Safe Prescribing and Dispensing

Last Updated: 01 October 2018

Body System: Musculoskeletal system,Skin

Safety

The Pan Mersey Area Prescribing Committee recommends:

  • All specialities, including haematology, should prescribe the methotrexate dose in multiples of 2.5mg tablets and the total dose in milligrams must also be included. For example, “Three 2.5mg tablets (7.5 milligrams)”;
  • Methotrexate 10mg tablets MUST NOT be prescribed or supplied;
  • Prescription and the dispensing label must clearly show the dose in milligram and the number of tablets to be taken and the frequency as “ONCE a week on the same day each week”;
  • prescribing of methotrexate with co-trimoxazole or trimethoprim is an ABSOLUTE CONTRAINDICATION and MUST NOT occur under any circumstances*. This contraindication applies to people that have recently taken methotrexate.