The Medicines Safety Assurance Tool (MSAT) is provided as a PDF document for reference. To request the spreadsheet solution of this safety tool, or for more information about this tool, to make a comment, or share a safety issue please contact email@example.com.
The MSAT was developed to improve the management of medicines related risk to patients. It is intended to provide commissioners with a systematic way of identifying and analysing emerging medicines safety issues and engage with providers to reduce medicines related harm.
The Pan Mersey Area Prescribing Committee recommends that patients or carers, or both, are trained and understand optimal use of their adrenaline auto injector device and are advised to carry two adrenaline auto injectors at all times.
Everyone involved in the support or care of people receiving clozapine is reminded of the importance of awareness and management of common side effects that may lead to life threatening conditions.
- Constipation must be actively monitored and actively treated. Clozapine carries a serious risk of intestinal obstruction including faecal impaction and paralytic ileu.
- Be cautious with signs or symptoms of a low white cell count. Clinical or haematological neutropenia or agranulocytosis can lead to an acute life threatening condition.
- Monitor closely for tachycardia. Clozapine also carries a serious risk of myocarditis and cardiomyopathy particularly in the first two months of treatment.
Codeine is contraindicated in all children aged 0-18 years who undergo tonsillectomy or adenoidectomy (or both) for obstructive sleep apnoea. Codeine is restricted to children over 12 years of age and only if the benefit outweighs the risks.
Domperidone is restricted to short term use in the relief of nausea and vomiting. The maximum recommended dose is 30 milligrams daily for one week. Contraindications include cardiac disorders, hepatic impairment, and concomitant QT prolonging or CYP3A4 inhibiting drugs.
Although emollients are not flammable in themselves or when on the skin, when dried on to fabric they act as an accelerant, increasing the speed of ignition and intensity of the fire. This accelerant effect significantly reduces the time available to act to put out a clothing or bedding fire before serious and fatal burns are sustained.
Overdose of methotrexate can lead to serious adverse effects such as haematopoietic disorders (leukopenia, thrombocytopenia, anaemia, and pancytopenia) and gastrointestinal reactions (mucositis, stomatitis, oral ulceration, gastrointestinal ulceration, and gastrointestinal bleeding). Some reports of overdose have been fatal. In these fatal cases, events such as sepsis or septic shock, renal failure, and aplastic anaemia were reported.
The Pan Mersey Area Prescribing Committee recommends that ALL clinicians provide GPs with adequate information about changes to patients’ medication regimes to ensure the accuracy of the Summary Care Record.